報告題目：上皮組織的力學研究：結構、剛性及流動性
Mechanics of Epithelial Tissues: Structure, Rigidity and Fluidity
報告人： Dapeng “Max” Bi博士，美國東北大學物理系助理教授
Assistant Professor, Department of Physics
Northeastern University, Boston, Massachusetts, USA
報告時間：2018年1月3日（周三）14:00-15:30
報告地點：新主樓B506
Cells must move through tissues in many important biological processes, including embryonic development, cancer metastasis, and wound healing. Often these tissues are dense and a cell's motion is strongly constrained by its neighbors, leading to glassy dynamics. Although there is a density-driven glass transition in particle-based models for active matter, these cannot explain liquid-to-solid transitions in confluent tissues, where there are no gaps between cells and the packing fraction remains fixed and equal to unity. I will demonstrate the existence of a new type of rigidity transition that occurs in confluent tissue monolayers at constant density. The onset of rigidity is governed by a model parameter that encodes single-cell properties such as cell-cell adhesion and cortical tension. I will also introduce a new model that simultaneously captures polarized cell motility and multicellular interactions in a confluent tissue and identify a glassy transition line that originates at the critical point of the rigidity transition. This work suggests an experimentally accessible structural order parameter that specifies the entire transition surface separating fluid tissues and solid tissues.
個人簡介：Dapeng “Max” Bi博士本科畢業(yè)于Binghamton大學物理系，于2012年Brandeis大學物理學博士學位。之后先后在Syracuse大學及Rockefeller大學從事研究工作，現(xiàn)為美國東北大學物理系助理教授。長期從事軟物質物理及生物物理研究，在顆粒材料的統(tǒng)計物理及生物組織的力學行為領域取得了重要的研究成果，在Nature、Nature Materials、Nature Physics、Physical Review Letters等頂級學術雜志上發(fā)表了多篇文章。
聯(lián)系人：徐曄（ye.xu@buaa.edu.cn）
