報(bào)告題目：魷魚(yú)晶狀體與皮蛋的相似性——生物體蛋白質(zhì)的自組織
Squid lens and Pi Dan: their material similarities
報(bào)告人： 蔡靜博士，美國(guó)賓夕法尼亞大學(xué)物理與天文系
Department of Physics and Astronomy
University of Pennsylvania, Philadelphia, PA, USA
報(bào)告時(shí)間：2017年12月19日（周二）15:00-16:30
報(bào)告地點(diǎn)：新主樓A849
Underwater vision requires a spherical lens to enable enough photon flux injecting into the camera-like eyes. The refractive index in the lens has a gradient to eliminate spherical aberration. Here, I present the squid lens system, where the whole lens is self-assembled using only one type of proteins. Using small angle X-ray scattering and computational methods, I studied how the proteins interact and the resulted in the homogeneous phase of the lens system. Results showed that the proteins are patchy particles with various patch numbers. The lens is assembled by distributing different patch number proteins at different radial positions to achieve both graded refractive index while maintaining transparency.
The lens system is very similar to Pi Dan（皮蛋） where the egg white proteins experienced a transition to form the gelled structure. We found that during this transition, the beta-sheet structure was preserved, whereas most of the other parts of the protein was unfolded. The unfolded part serves as the patches and the gelled structure was formed by this attractive interaction. At the end, I also compared the Pi Dan to the squid lens, and generalized the requirements of proteins as patchy particle that form transparent gels.
個(gè)人簡(jiǎn)介：蔡靜，美國(guó)賓夕法尼亞大學(xué)物理學(xué)博士，現(xiàn)為該校博士后研究員，曾在摩根大通銀行從事核心建模。其科研領(lǐng)域主要集中在生物系統(tǒng)的自組織結(jié)構(gòu)。以第一作者的身份在Science上發(fā)表題為“eye patches: protein assembly of index-gradient squid lenses”的論文,受到了廣泛關(guān)注，被Nature Photonics，Physics Today等雜志轉(zhuǎn)載，并被諸多公共媒體報(bào)導(dǎo)。攻讀博士及博士后期間，數(shù)次在American Physical Society March Meeting等國(guó)際會(huì)議上做相關(guān)學(xué)術(shù)報(bào)告；并參與了包括Physical Review Letters等國(guó)際知名期刊的評(píng)審工作。
聯(lián)系人：徐曄（ye.xu@buaa.edu.cn）
